Systemic fungal overgrowth is real

Specifically it’s candida. It’s so much more than a “yeast infection.” I just finished once daily 100 mg mycamine (mifungin) infusions. I did this for three weeks via a PICC line. The last week really did the trick. After two weeks I felt like I was 75% or so there. I compared it to being most of the way through your antibiotics course for an infection. Previously, I was almost permanently fighting oral thrush and the visible thrush symptoms would clear up but multiple symptoms with my throat never would. Finally, I insisted and my immunologist did a throat culture – for fungal. It came back in a week for candida. It really was everywhere. I can’t even imagine the stress this was putting on my gastrointestinal tract.

Side note, getting information on candida overgrowth (on the Internet) is maddening because people have such strong opinions about it.  It also might be worth noting there are multiple antifungal oral options. There was something about every single option – either the active ingredient or an inactive ingredient – that meant it wasn’t possible for me. If you’re looking for information I would recommend limiting your searching to Google Scholar. You might call this post a follow up to my previous post about looking for information on fungal overgrowth. I’m also not particularly high risk, like organ transplant or HIV.

Because of the symptoms that have utterly disappeared after the three weeks of infusions, I can say unequivocally that I’ve had this problem for years. It increased in severity in the past 9-12 months. Based on my research, it’s possible that just having multiple sclerosis increased my risk. (No idea how, but I saw more than one academic journal article mentioning it.) Gastroparesis also increases your risk, but this makes sense considering that food sits longer and has more time to basically ferment in your system. Also, eating gluten free and drinking more milk doesn’t help because there’s more sugars to feed the yeast. I suspect MCAS increased my risk too.

Also, to be clear. This is completely amazing to me. Dealing with the PICC line, the infusions, and the systemic symptom blow up from the mycamine itself – because it caused a mast cell flare up – was ultimately worth it. On top of this I can’t put into words how astounded I am that I dealt with this for so long and this candida was just ON ME AND IN ME AND EVERYWHERE.

So, my symptoms. I think a list might be easiest. Most of these symptoms have disappeared. Yes, I’ll say it again, disappeared. Just my skin alone feels better.


1. Itchiness. My scalp would get unbearably itchy if I didn’t wash my hair at least every 2 to 3 days. A thousand times worse if I sweated a lot. My entire body would be itchy if I didn’t shower every 2 days at minimum. I had accepted that my skin was so sensitive to everything that I just needed to shower every night as often as possible. I know this to be true because I also washed my hair significantly less during the infusion treatment because of the PICC line and experienced no negative effects. I would have intense under arm itching occasionally too. 

2. Smell/Odor. My bad breath is gone. (My husband might admit to how bad it was if I prod him some more.) My body odor itself is no longer as strong. I could never figure out why I seemed to smell sour after sweating more or showering less. Maybe like three day old beer? (That is so gross I can’t even begin to figure out which emoji is best.) It was unpleasant for me so I have no idea how it was for people around me. But a gradual change in your body odor is not really something you remember to ask the doctor about.

3. Eczema on my feet. A fungal infection on the heels of your feet and around dead skin does not look like a fungal infection on flat skin. I think the yeast was actually worsening eczema on top of causing other issues.

4. Residue. I don’t know what else to call it. The best example is what happened to my underarms. Some time long ago I realized I had this white pasty looking substance under my arms. My under arms were so sensitive I had to stop shaving. I would trim the hair with a simple battery operated trimmer. There continued to be this residue that looked a lot like built up solid antiperspirant/deodorant. I assumed it was a combination of dead skin and deodorant. It was actually reasonable to assume I was allergic to my deodorant.

There’s other parts of my body that has a similar type of “residue” that’ll I skip the details on. Belly button is probably an obvious one. Come to think of it, it was EVEN MY EARS. Basically, if it’s dark and/or moist there was probably a strange white build up if I didn’t shower/clean regularly. I’ve also just realized that I could have the same build up across my skin if I wasn’t able to do something as simple as rub down the length of my arm with a wash cloth in the shower. (Sorry, that’s a horrible sentence.) So, it was everywhere on my skin and if the area was moist (moister?) then it was worse.

I think that’s a good segue for switching to internal, wouldn’t you say? Some of these symptoms I’m not sure how much the yeast overgrowth contributed and how much is from my chronic diseases.


5. GI symptoms. I have less gas. I’m wondering if removing the inflammation caused by the yeast overgrowth will effectively reduce the severity of symptoms from my gastroparesis.

6. I couldn’t wear tighter clothing – like yoga pants for more than 10-12 hours. Actual leggings which are slightly tighter was even worse. Let me put it this way: chronic vaginal yeast infections do not have the tell tale white … substance. You get “irritation” instead. I put the word irritation in quotes because it seems like an understatement. More time will tell.

7. Sore throat and pain when swallowing. I would wake up in the middle of the night to pee and have a super painful spot in the back of my throat and it would happen again in the morning. I could lose my voice after lots of talking. I think I was drinking more water to compensate for this too. Sore tongue but you couldn’t see it so doctors didn’t believe me. I think I had a layer over my tongue that you couldn’t see without scraping. There was also the sensation of something at the back of my throat or tongue. It’s not something you can easily ignore. (MS can cause problems swallowing, so how was I to know?)

8. A bad taste in my mouth and a weird change to my saliva. I have a suspicion, that might be confirmed with my next dentist appointment next week, that the yeast was interfering so much so that I was at higher risk for cavities. I had all these tiny little cavities 6 months ago and I don’t drink much that’s carbonated, let alone anything like regular soda. The actual consistency to my saliva was also weird and well, wrong. How would you describe it? It was weird.

9. I think maybe my eyes had issues too. It’s weird to consider, hard to describe, and it wasn’t as severe as other parts of my body.

10. My bladder. I already have chronic symptoms because of MS. If I really was drinking more water that wasn’t helping. I might have less inflammation here too, but more time will tell since I was also on prednisone through the infusions.

11. Clearer sinuses and nasal passage. Over the past few months I’ve noticed an increase in crap in my sinuses. Like I was more congested and actually started using sinus wash more. Anyone who uses sinus wash probably understands why this is significant.

12. I should have less systemic inflammation too. This might lead to improvements in my levels of chronic pain and chronic fatigue. Maybe this will help my MCAS be less likely to flare? My migraines had worsened in severity this year, I was experiencing less but they were lasting longer.

13. INCREASED sense of taste. I can remember wondering why some foods seem so bland. I would also search for stronger flavors. The build up of yeast in my mouth was getting between me and my food. As a specific example, there’s a dark chocolate truffle flavored with bergamot among other things that tastes stronger to me. Food might actually be more enjoyable. More time will tell on that one too. Anyone with major food sensitivities and diet restrictions can best appreciate why this improvement is wonderful.

My symptoms had become so widespread and, well, all consuming, that I have realized some things as I’ve written up this blog post. It’s been a crazy experience.